Make sure you're not stopping at absolute difficulty when you should really be thing about difficulty in the context of technological capability. The near-arctic is a remarkably hostile environment, but humans can live there and thrive with only stone age technology. We are
far beyond the stone age level of technology. The number of places that private citizens can live is far expanded as a result. (There are actually people now who have privately-funded undersea habitats!)
The decision of some individuals to move from the british isles to N. America for religious reasons happened in a specific economic, geopolitical, and technological context. If the available vessels and navigation were poorer or more expensive, it would not have happened, and they would have done something else. You have to consider these things in their specific context.
So, given a strong enough desire for people to live "in space" or "on Mars" or "on Venus" combined with the technological and economic wherewithal to do it, people are going to try. Combine this with very wealthy national powers led by a class of engineer-technocrats with a demonstrated track record of implementing multiple decades long-term payoff projects (China) and the conclusion I come up with is that there is a significant chance that we will wind up with civilizations elsewhere in the solar system.
Also, the specific environment they're talking about in the article isn't anywhere close to the Mariana Trench. It's at about 1 atmosphere pressure. The most hostile thing about it would be constantly encountering sulphuric acid clouds. (This would also be a tremendous benefit, however.) Another important difference: The physics of building livable volume favors by far Venus human-aerostat altitudes over the Marianas Trench. Equipment for working "outside" in that specific Venus environment is something we already have a good idea about implementing inexpensively. The basic physics of the Marianas Trench makes doing the same down there orders of magnitude harder. Likewise, other basic physics around energy would preclude economically feasible agriculture in the trench, but indicates that it's quite doable at those altitudes on Venus.
A Venus colonist would probably sing songs praising PTFE. (One's already been written: "Polytetrafluoroethylene -- that's Teflon, you @ssholes!") Fortunately, we already know that one could condense fluorine directly out of the atmosphere of Venus with basically just energy as input.