Were you comparing Safari with 0 extensions vs. Chrome with 0 extensions? Or does each have a different extension load?
I will often fall back to Safari if a page doesn't render properly in Chrome, but that's because I installed a bunch of extensions on Chrome and have consciously left Safari pure as the driven snow. It's a different problem domain, but I know certain extensions can use resources in surprising ways.
Chrome burns 90% of a CPU on one thread, and another 40% on another. Coconut reports about 32 Watts used. Safari maxes at about 12% plus 8%, and tops at about 15 Watts. Base usage on this machine with the current screen brightness and applications that happen to be open is 10-12 Watts. I get approximately the same results with Incognito mode, which suggests the problem is core Chrome rather than add-ons.
What's especially obnoxious about that behavior is that if you disable the dGPU, it works just fine. So what's the point?
Also, one would expect Chrome's own Web Store to work well in Chrome... but Google's attitude toward long-standing bugs is anything but exemplary.
Generally, this just makes things that bit faster. The more you can store in RAM (even trivial things), the better. I've never had any slow downs, and don't have to worry about opening Photoshop and Illustrator along with XCode, Sketch and 20 Chrome tabs.
Unless you're a true poweruser, no one really needs more than 8gb by todays standards. I have 32gb because I maintain and develop 4 different codebases each with their own setup in different VMs. If I didn't do that, I could manage with 8gb just fine.
Why? Genuinely curious why anyone would ever need that many tabs open. Why can't you use bookmarks/reading list? It doesn't seem possible that you would be actively using all of those regularly enough to need them all open.
I'm currently running with 19 tabs open. Any more than that and it becomes too difficult to identify them. Ideally, I try to trim it down to about 10 when I can. How anyone can be even remotely productive with 300 open is beyond me.
Now, 16GB, that's very good