Is the performance difference between Django+TastyPie, Flask, or Falcon really going to be the bottleneck holding you back from achieving greatness? If so..then maybe it's better to consider a different tool set.
Any number of other high-performance solutions fit the bill: Go, Java JAXRS, etc..
After having spent over a decade in Python-land myself, I've learned that a Framework's ease-of-use by developers is vastly more important than any micro-benchmark performance.
When I evaluated Falcon for it's usability in mid-2014 I found it painful when compared to Flask or Bottle.
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But if benchmarks are your thing, for laughs, I've found some which compare Go / Python / Java etc (hey, at least they are data-driven :) :
https://www.techempower.com/benchmarks/ - here "Falcon" scores below Go, Java, and PHP frameworks.
http://ziutek.github.io/web_bench/
https://medium.com/@tschundeee/express-vs-flask-vs-go-acc087...