For many (most?) startups in the valley, if you aren't living in the greater SFO area, or willing to relocate there, they are not interested.
They are dinosaurs living in the past, fighting distributed collaboration. (Which is ironic as they are technology companies). Importing people from overseas to the bay area is actually the hard way of solving the problem.
From first hand XP, I can tell you going distributed has made hiring top notch talent 10x easier. And if I hire someone overseas, they don't have to move...
Again, IMHO all the excuses like "culture" are bullshit, if your culture depends on holding hands as a group every day, your company culture is already fatally weak.