True horror story: The first board I was involved with when working at Lucent in 2001 was a monster modem card, provided something like 300 modems plus or minus. For a long time in the development process we had a weird reliability problem which just could not be tracked down. Until in desperation a hardware engineer started putting his scope probe everywhere ... and found a line (or set of them) where the signal was messed up in the middle but not at the end!!!
Analog is a black art.