He has a congenital deformity of the arms, but he can type (and is one of those clacky-IBM keyboard fetishists). With his feet, he can use mice and controllers. But multi-touch systems are beyond his ability - while he can pivot and shift to type remarkably quickly, he can't get more than one hand on something at the same time. Worse, each hand is effectively only one digit for him.
And then, there are the folks who don't even have his degree of dexterity.
I can't help thinking that it might be a good thing for general interface designers to consider the implications of disabilities for users of these designs, instead of shrugging that off onto providers of interfaces specifically for the disabled.