Your long track record in a fortune 50 company might be the thing that steers you away from getting accepted to such companies. If I was hiring you, the first red flag I'd get is 'this guys experienced' - how much is this going to cost me?
Likely, the jobs at small disruptive companies probably work on recommendations. I see your options like this if you want to make the change:
Option 1: Get a recommendation to a company your interested in and expect a pay cut.
Option 2: Find a startup that you're interested in, offer to help them out, make connections; or, join one.
Option 3: Start your own B2C startup, do it as a side project, build a team and quit your day job when you're ready.
There is nothing worse than doing a job that you're no longer interested in. I know your pain, everybody has been in your shoes at one stage in their life.
This is my email, your welcome to email if you want any advice, lukejamesfitzpatrick@gmail.com