I've had Five Finger Sprints for about a year now, and have been heavily evangelising them to my friends. Running barefoot really does feel liberating, especially going off-road through parks, fields and trails. It's like being a kid again and definitely bought the fun back into running for me. I can really hammer out the miles with them now, zero sore legs or calves. :)
It took me about a month of a few runs per week (20-30 mins) to adjust -- so not long at all. One of the mistakes I made at the start was going too far, too fast: I tried to do my usual 1h+ runs straight away in the Vibrams and was pushing-off from the ground, concentrating on staying on the balls of my feet. Bad idea.
Anyway, here's some tips from someone who has been through it:
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- Relax, relax, relax.
- Don't push off from the ground, rather, concentrate on lifting your thighs.
- Don't aim to balance on the balls of your feet. You're not running on tip-toes, and that's going to put insane strain on your calves. Instead, get the general area of the top half of your foot to land first, almost flat-footed is fine.
- Aim to tap the ground with your feet about 2-3 times a second, as if your feet are going in a circular motion, and passing by the ground. It's like you're incidentally propelling yourself along with gentle touches to the ground.
- Keep hips relatively low, legs relaxed, leaning slightly forward. If your calves start to hurt, then relax more.
- You will get sore calves as your feet and leg muscles get used to the new style of running. Stick with it, and don't overdo it.