- I follow a couple of industry professionals and companies to stay up to date with their updates. As a MSFT developer I follow MSDN, the .NET team, but also important players like Scott Hanselman and Scott Guthrie. By doing this I always get the latest updates.
- I never follow more than 50 people and unfollow everyone who posts too much... If there are so many tweets that you don't have time to read them, you're not being effective. Be picky about who you follow. You don't have to follow your followers in return.
- I use Twitter a LOT to communicate with people I'd otherwise have no access to, because I don't have their email or they are too busy answering me through the company mailbox. Twitter makes everyone (except for celebs) reachable. If I need some guy at Google who write library X, I just send him a tweet.
- I use the search to find what people are saying about my product, but sometimes I also use it to engage with people who are talking about a subject I'm interested in.