That's the inevitable consequence of being overambitious. This pattern is the same, regardless of the area within which these folks try to become more powerful, rich or famous than others.

At BMW a former director told some trainees that he's the most lonely person in the world. Lost his wife, kids and friends. Hobbies? None. Money? More than can be spend. Power? You bet. "Too soon old, too late wise" is true even for extraordinary achievers like this guy.

I always like to point out to those younger folks that they need to be aware of their true motivation. To 99 % in the startup scene or at the big companies it's not to make the world a better place. It's not to be creative and productive. The main drive is ambition. That's OK, it's human. But it needs to be controlled. When you are aware of your true selfish motivation, it's easier to stop when it's all too much. You do it for yourself, not your family (you would choose a solid 9 to 5 job) or the world.