As an aside, I always thought that, while science was expensive, chemicals were cheap. But this article's ballpark figures are about hundreds of thousands of dollars per dose for drug production in small scale.

I know it will vary wildly from drug to drug, but, in general, does anyone know if it actually costs that much to manufacture a single dose?

Also, what if a rich, terminally sick person decides to break the law and manufacture a promising experimental drug for her own use in her basement? The chemical formula is in the published papers, after all. How many specialists would be needed in the conspiracy?