Sikuli Script lets me script almost anything that has a visual element/gui. I've been able to automate just about any task that has a gui and is repetitive, in some fashion or another, and at this point I have a backlog of scripts for working with some of the esoteric software I encounter day to day. Definitely worth checking out if you haven't before.
The multiple cursors (which are getting prominent in a lot of text editors) are awesome for small text munging and manipulation. by and large, everything I could do with multiple cursors could have been accomplished with some other tool, such as regex's or whatever else, but the multiple cursors end up being really intuitive and powerful for me. I never have to rethink how they work because they work just like my normal cursor but... with more of them. Combine them with ST2's ability to do a search and place cursors at every found location, and I can get a lot of weird stuff done quickly.