With any luck we might finally realise that we're not dealing with "documents" anymore, that HTML, JS, and CSS do not a good UI framework make, and that JS simply isn't good enough for what we need it to do and how we need it to do it.
ECMAScript 7 will be pretty much ready to implement and the standards committee will realise that they've run out of syntax for ECMAScript 8, forcing a rethink. Fingers crossed a neckbeard will arrive and point out that a LISP would be ideal for both defining the "DOM" and providing a base language for targeting by other languages, who can just (ok, "just") serialize their ASTs and pass it in.
Seriously: if, in 5 years, we're still perfecting the dominant user-facing runtime by tweaking an arbitrary XML spec, a language with only one kind of number, and a styling language so inept it almost requires auto-generation tools, well I might just kill myself.