a) when there's an operational deficiency (and you have the wherewithal to solve it), and
b) when there's a management deficiency (and you have the wherewithal to solve it)
I imagine that's every bit as true on the web as it is offline. So from where you're standing, do you see an opportunity the current owner is missing? Do you have the skill and resources to install that value? If after a good hard consult with your gut you can answer Yes to both questions it may be a good idea to move forward.