I have always had a huge problem with the non-reproducible nature of medical research and its acceptance within the field. Being in medicine, every day you hear a physician citing some study from 15 years ago conducted on a sample size of 20/50/100 or so patients as a way to justify their clinical decisions. And it always worries me that we tend to put so much faith in these "landmark" studies, as if their findings are somehow legitimate and true because statistical significance was reached at least once, and seem to forget all of the misaligned incentives and game-playing that goes on in research, and the amount of data burying by the FDA, all that almost certainly influence and manipulate data, publication, etc in a negative way.

I tend to take the majority of medical research with a grain of salt, for the reasons listed here and in the article, unless there's some very convincing meta-analysis or successfully reproduced evidence. Call me overly cynical, but that we calculate a parameter or administer a drug or change our methods because of some article you read last month in NEJM is beyond bogus.