That depends on the port. The Clojure port allows this:

https://github.com/hraberg/shen.clj#神-define-prolog-and-defp...

From[0], the answer appears to be yes, but it greatly depends on the host. One can write Common Lisp code by using uppercase. Using $native will execute the following code as Scheme code. For Clojure, it looks like Shen provides a FFI for basic interactions.

[0] http://www.shenlanguage.org/learn-shen/native.html