Interesting and quite dense post - I had some trouble with the terminology so, for the other five people reading this.. CHO = carbon hydrogen oxygen (ie carbohydrates), N = nitrogen (ie proteins & purines)? This was hard to figure out from google alone but seems to make sense..

Also, PUFA = Polyunsaturated Faty Acids, EFA = Essential Fatty Acids. n3/n6 are more commonly (less precisely?) known as omega 3/omega 6 fatty acids.

From my personal, anecdotal experience the first intervention has been effective (and this seems to accord with the received recommendations wrt better health outcomes for those eating more vegetables and fish). But how clear are we on the outcomes of these simple and broadly applicable interventions have been made clear and concrete so far? The first goal for the science should surely be to end the debate on the proliferation "diseases of civilisation" which, to my understanding, we should be able to do by proving a difference in outcomes for these interventions and correlating them to the dietary shifts of the last 30 years