I know this is anecdotal. But does anyone else know have counter experiences or tweaking recommendations? I sync maildirs with mbsync/isync and use notmuch. I could use the notmuch Emacs interface as well, but it does not do some delete operations and other things that require frequent access to raw maildir access (notmuch indexing will not delete maildir emails, but syncs all other flags). Mutt-kz (mutt with notmuch extensions) is pretty much my current sweet spot.
Anyone else where I am at? It is so hard to part with the efficiency and simplicity of mutt once you adapt.