I think a serious contribution to Founder Depression is that we're always expected to be on. If anyone asks about your startup you're supposed to be super-motivated, encouraged to give off the appearance that everythings a-ok in case word might get out to investors/competitors/etc.

The reality is that some weeks/months really, really suck. If more of us recognised and accepted this fact then I think it'd go a long way to combatting FD.