For instance, the context-switching cost is very true. It's better to focus on one thing at a time, and multi-tasking is endemic to our society. If you can focus on one thing for a few days with no distraction you can really accomplish mountains especially compared to the usual email/social media distraction dance that is seemingly normal for anyone with a smart phone these days.
However on the flip side, compressing learning that is intended to be absorbed over a few months into a couple weeks of sleepless nights is a surefire way to make sure your retention is absolutely squalid. We used to call this cramming, it allows you to pass an exam, but it's well-known that it doesn't lead to much in the way of long-term learning.