Ha. I just moved everything in my downloads folder to an "Old" folder to get to downloads zero. 28 gigs, I don't know why I'm holding on to it. I do the same with desktop icons.
When I run daisy disk, the folders with the most used space are Virtual Machines, Downloads, and Desktop
Daisy Disk looks cool. I've been using the free OmniDiskSweeper which gets the job done just fine, but isn't as pretty.