There is no doubt that what Wolfram Research has done with Mathematica is amazing and tempting. It is a very complete and uniform engine, and can be very useful for very different kinds of mathematics.
However, Wolfram Research deliberately keeps their methods and source code closed. Note that this is more serious than just the "Stallman-esque" open-source-everything philosophy. Wolfram insists that users do not need to know implementation details of their methods. This is plainly in their documentation. You can see the uncompelling argument from Wolfram here [6]. The gist of the argument is that interfaces matter, not implementations.
I strongly argue that users, especially mathematicians and engineers, should care about the internals of mathematical software, especially when it's being used, even in a utilitarian fashion, for research and engineering.
Not only this, but Wolfram has litigated against his own employees for publishing mathematical proofs about cellular automata. Information about this lawsuit is sparse, but evidence of it can be seen in [0]. More information can be found here [1].
Unfortunately most responses to the above from users of Mathematica is "well I just use Mathematica as a calculator, nothing serious" or "I wouldn't look at the source code anyway, so what gives?" It's an unfortunate response, and I don't have a technical rebuttal, but a moral one, which many don't want to hear.
It pains me to see the technical reliance on Mathematica (and other software such as MATLAB) in professional mathematicians, scientists, and engineers. It reminds me of an addictive drug; one of the best hackers I know does their work completely in Mathematica, and can no longer work without it.
As is the case with a lot of closed source, proprietary software, there aren't a ton of good alternatives. There is a plethora of logistical issues with existing computer algebra systems, but I nonetheless recommend them. Sage [2] is a continuously growing system based on Python which has backing from a lot of mathematicians. They are continually improving it. There's also Maxima [3]. None of these has quite an extensive array of functionality and graphical capabilities as Mathematica.
I (and others) have written more about this issue more extensively here [4] for those interested. This is an extension on the article written by Jordi G. Hermoso [5].
If you took the time to read this, thanks.
[0] https://groups.yahoo.com/neo/groups/theory-edge/conversation...
[1] http://vserver1.cscs.lsa.umich.edu/~crshalizi/reviews/wolfra...
[3] http://andrejv.github.io/wxmaxima/
[4] http://symbo1ics.com/blog/?p=69
[5] http://www.symbo1ics.com/files/jordi.pdf
[6] http://reference.wolfram.com/language/tutorial/WhyYouDoNotUs...