Against that benefit was the consideration that there could have been comments that weren't diffscuss threads in a diff, and that would have meant that you could have legal diffs that would have terribly confused any diffscuss parsing.
Add to that the fact that you can get a legal diff back just by piping a diffscuss file through a single grep -v, and we decided not to use # (which I think was probably the right call--overloading comment syntax for functional stuff always creeps me out a bit anyway).