Most families these days are started by parents in their 30's.
http://en.wikipedia.org/wiki/Image:Trisomy21_graph.jpg
I wouldn't even consider starting a family later than 35. And look at 45! More than a 1 in 33 chance you will have a child with Down syndrome (Trisomy 21) after 45...those are definitely not gambling odds.
And this kind of risk to the baby is not nearly as serious as a risk to the mother. You can always try again. These are the stats you should be considering.
I think though, at 35, you may feel a little differently about those risks, especially given that down syndrome can be detected in-utero.
Do you mind explaining? It seems like I see more and more people having children after 30, even 40 these days.
On the other hand some men would not consider that to be a problem at all (assuming you can find a mate). And if you're a 40 yearold millionaire you shouldn't have a problem finding a 20-something to have a kid with. :-)