I don't know how to phrase this properly, but how long does the blood maintain the youthful qualities? Do you constantly need new blood coming in from a young donor? Do you receive it once and you're good for a week? A year?
In any case, this will never turn into cross-generation blood transplants on a regular basis. The present system of medical regulation is heavily biased towards demonstrating mechanisms. If you can't explain your mechanism you are not getting approved by the FDA, or at least not until such time as everyone else in the world is already doing it and the bureaucrats are made to look bad - see the last decade of stem cell transplants for the way in which that happens.
So the attempts at therapies that result from this will likely be delivery of proteins or interference with proteins to put a thumb on the scales of metabolic machinery. At which point it lasts for the period of time in which you are getting regular injections.
For eg, This one had them connected for 2 weeks : http://www.ncbi.nlm.nih.gov/pubmed/24145664
anyway, we need to wait for more research on similar methods.
Anyway, yes, why not try this on humans? Sounds perfectly reasonable.
Lots of donated blood expires and is tossed. Make a program that all blood about to expire (1 day away) can be used for this.
As mentioned in the article:
"Waking up stem cells might lead to their multiplying uncontrollably."