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The query language is embedded in legal Clojure data structures, so it would be tricky to port to JS. That's a drawback of embedded DSL's I suppose.

Contingent on the design but not necessary. I could make something similar in PureScript.

I wouldn't use Datalog though, I got turned off on it after using Datomic at work.

Similar to Datomic, which has Java bindings and allows for query DSL be specified just as a regular String, we can do this for JS interop