If you can't get traction with licensing to a big partner, I would start with pillow cases since you mentioned the acne use case. That's something smaller, easier, more personal, an impulse purchase almost (even if online). You could do a kickstarter, or set it up as a small business.

If you think about people who suffer acne, a lot of them are young, even young enough to still be living with parents. It's possible their parents still change their sheets for them, lol... so the end customer isn't really as involved with the purchase, with sheets. But pillow cases, on the other hand, the end user will take things into their own hands, and it's an easier sell.