I spent a semester doing this in college, living in the city where my school was located during the weekends and living in a student city a few hours away to work an internship during the work week. I would bus between the two every week. It definitely spread me thin (working full time, classes and papers at night, research on the weekends, plus somehow still trying to have a social life) but it was an incredible experience to live in an awesome new city. If you have a reason to go for it and don't mind spending the time on the road, why not give it a shot? You can always decide on one place to settle down, and you'll know what it's like to actually live in each of them