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At least one of the 12 seeds wins almost every year. An 11 seed upsetting doesn't really impact the odds much.

Not that anyone is going to win his money, but this one game doesn't change anything.

In absolute terms, you're right. But in relative terms this just eliminated the majority of brackets. And since Nate Silver's bracket is probably one of the more intelligently picked and widely disseminated out there, a huge number of the people who probably had better odds of winning just got knocked out. So in relative terms, it absolutely changed things.

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