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We've been using MapBox and are pretty happy with it. They are filling a much needed niche for businesses that are not big enough to be able to afford the $10k google license. We have had good success leveraging their tools for non profits and small to mid size businesses.

Another happy MapQuest user here as well. We saved tens of thousands a year by switching from Google Maps to OSM/MapQuest. Leaflet [1] is also a big feather in the cap - easy API, actively maintained, and it easily integrates with any number of tile providers with no provider-specific code.

[1] http://leafletjs.com

I was actually planning on writing a CloudMade/MapBox comparison, but it looks like there's no need anymore.

It's tough to compare the two - each has services that the other doesn't (aerial imagery, routing, geocoding, etc.) so you might end up with an implementation that cobbles together things from both.