Between the harsh northeastern winter, and whats happening in San Francisco, we're making a big push to attract folks with low cost of living and high quality of life in Myrtle Beach, SC through http://WhyNotTheBeach.com.
With so many companies becoming more and more open to remote workers, remote teams, remote offices, I think more cities will have the opportunity to attract highly paid, highly talented individuals for more quality of life reasons instead of congregating in tech hubs.
It just comes down to demonstrating that the resources are available locally, or have advanced enough online so that you're not at a disadvantage. One argument to being in SF is everyone is competing for talent, funding, etc. from the same sources. There are investors and talent elsewhere who would love to get in on opportunities, and I think that can start to turn the tide.
As a transplant from Boston, MA to Myrtle Beach - I was overwhelmed after being in the Boston startup scene and involved with TechStars for 4 years. Boston certainly isn't at the SF level, but I still believe there are compelling arguments for those in Boston, NYC, Philly, SF and elsewhere to consider alternative cities with low cost of living and high quality of life. Time will tell!