That'd be pretty close to the top of my list.
A quick 2-3 mile jog around the neighborhood can help get me out of work-related funks. (I work at a home office, though, so it's easier for me to say "fuck it" and go do something sweaty in the middle of the day...)
My theory is that, since the only real item on your jogging to-do list is to put one foot in front of the other, your brain is freed up a bit to wander. Which is helped by the light stimulus of the changing environment around you. And this brain wandering helps shake out cobwebs and generally make you feel like a free individual again.
And, of course, it gives you an energy boost, which helps with the simple exhaustion side of things.