How about cycling?
Contrary to common sense, stick to the major roads. The traffic flows better and you don't have to gamble w/ stop signs.
Also the bad neighborhoods always seem to be in the valleys, which, unless you're Lance, is where you'll be riding. So follow the crackheads for the least hilly route.
I don't care if I get hit a few times. Driving is maddening in this city. I only use my car to meet w/ folks in the valley and to surf or get out of town.