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The technology is not that relevant but there's still a lot to learn in how he approaches problems. In that respect, It's much more timeless than a typical technology focused book.

I've learned a lot about what to optimize how to go about it and when to optimize from reading his book and I use a lot of this insight even now when working on performance optimization for web applications.

Together with SICP, it's one of the books that influenced me the most.

I wrote a blog post yesterday that may be of some help to you

www.renderingwithstyle.com/post/74997233849/ten-things-you-should-know-about-shaders

Not relevant at all, unless you are interested in a historical perspective.

Or if you're doing something like implementing a software rendering in a constrained environment ie 4k demo or Java 4k Games contest.

Afaik even 4k demos are mostly shaders these days.

Only remaining place for software rendering seems to be the embedded world. But if you are trying to make quake-level graphics on an µc then ... you are being awesome :)