I'm not sure that there are any opportunities for micropayments. It seems like a solution looking for a problem.
Doing this via a global blockchain might not be viable, of course.
(✓) Public reluctance to accept weird new forms of money
(✓) Huge existing software investment in SMTP
:) (✓) Sending email should be freeActually, if the amount is a flat or mostly-flat rate then most e-mail exchanges would be effectively free (send message, get response, net cost = 0). I'm not sure how it would work with mailing lists/groups though...
Further, that physical spam is really, really well targeted compared to email spam. You may not care about most of it, but at least it has something to do with your real life (mostly coupons and advertisements for local businesses, if yours is like mine).