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I really really from all of my heart wish that your project will work. Seriously, the idea of a free HIV vaccine is amazing. But honestly, I believe that you might all be a bit naive when it comes to doing proper molecular biology experiments. There's a reason why most PhD students need several years to finish their studies and they mostly use just a few techniques. Doing experiments with humanized mice and HIV might sound easy on paper, but will turn out to be way more complicated than what you believe it to be now. Trust me, been there, done that. Anyways, I wish you all the best, I love it when people challenge old dogmas with new ideas. I'd appreciate it a lot if you could put some more information about the biology, especially the role if the immune system, online.

While I appreciate that it's possible to cut down the upfront costs with talented staff, it still seems that things like clinical trials will cost hundreds of millions of dollars (at least that's the price range I've seen for anti-malarial vaccination clinical trials) and still have a substantial chance of failure at later stage trials.

It would seem difficult to raise that kind of money from other than big pharma or typical pharma capital market sources who would want to see a large pay-off from such an risky investment (i.e. selling it in countries which could afford it).

Best of luck in any case!

It is not unlikely that some developing country like India, Brazil or Nigeria could pony up the money and provide access to regulatory fast tracks if the research seems promising enough.

That said, what's your bus factor like?

https://en.wikipedia.org/wiki/Bus_factor