As long as you keep your design to short lived HTTP requests in CRUD fashion - and no deep nesting - It is possible (REST is really procedural in its core). In fact, I would suggest the model for any scripting language. That do not mean you cannot use OOP SDKs for which you can make calls within procedural code. I typically use Java for complex logic which is mostly run as cron/long lived process often with multiple threads. My CRUD files rarely exceed 1000 lines of code and do not do any UI heavy lifting (left to HTML/JS). I use AWS and SDKs wherever applicable to remove heavy lifting from my code and keep things stateless as possible.

In the past 2 years we have developed a Mobile Companion Platform for TV which scaled to many hundred thousand users, a scalable appstore for TV, a Middleware Platform for HTML/Android Set Tops, a mobile Live TV platform and a Campaign Management System for TV. I find it exceedingly difficult to manage and scale containers and would not use them for anything other than strict enterprise stuff.

Our platforms typically have 80-100 CRUD APIs and finish within 10000 lines of PHP with heavy lifting delegated to cloud APIs and Java based crons/long lived processes.