I can still see a potential method of rewriting functions, whose arguments were decorated with type specifiers, to provide type checking. But that would involve prefixing the function body with type checking code to be evaluated at runtime, which would probably produce a monstrous increase in execution time, and would be ugly either way.
Well. I suppose I shouldn't have expected anything different, knowing that a real macro system requires support at the language level, and that a retrofit like sweet.js is perforce going to be limited in what it can hope to accomplish. But I find myself disappointed nonetheless that sweet.js is what it is, rather than what I wanted it to be -- and, I think, what a lot of people, not least of whom the author of the linked article, imagine it to be.