If a novice took over the layout of your favorite publication, offline or off, you'd probably notice.

Having a desktop environment where things "look right" is, to me, the same as working in a room that is clean and tidy.

People who are educated in micro typography (The field of Graphic Design distinguised between macro and micro typography), see this difference instantly and everywhere. It's like reading: onec learned you automatically process whe you see letters.