Fedora running on an Intel Core 2 Quad, 8GB RAM, Intel 320 SSD, ATI FirePro V4900 (http://www.amd.com/us/products/workstation/graphics/ati-fire...) w/ 3 displays.
I switched from 2 Nvidia cards (2-head and 1-head) to 1 ATI 3-head card because the Nvidia drivers stopped liking that two-card combo after Fedora 14/GNOME 2.
The only issue I have with this setup is too many Chrome tabs (100 or so) can bring things to a halt. Does anyone know a trick to deal with the Chrome-tab issue?