Considering that it "only" took us several thousand years to transform ourselves from hunter-gatherers to our current technologies, it makes little sense that this is the first human culture to reach the point we've reached. Then I try to dissuade myself from such a notion, rationalizing that if that were the case, we'd know it from some sort of evidence by this point.
And yet, I still can't shake the notion that this "shouldn't" be the first time around. Weird, especially since I consider myself a hardcore skeptic.