I feel there's a much higher chance that humanity will drastically change its own fate (for better or worse) in the next hundred years, and any forecasts beyond that have very wide error bars. Artificial intelligence is the big one (it ends the current era of "business as usual" no matter whether it's friendly or not), but there's also nanotech, superviruses coming from desktop bio-hackery, mind uploading, good old nuclear terrorism, etc. For "business as usual" to continue and things like climate change to stay relevant, we need to dodge all of the above, which is difficult.
For a more thoughtful take on the future of humanity, Google for the keywords "existential risk". Bostrom's writeup is a good start: http://www.nickbostrom.com/existential/risks.html