This is rubbish. What matters is how many packets of data go through the network. It is packets which are the unit of transfer and which are handled by intermediate nodes. The difference between say 2340 and 2290 bytes is of no material consequence whatsoever, it may cause one less packet to be sent but probably won't. To think it does have a consequence is to demonstrate a complete lack of understanding of what happens in the network and in endpoints. None of these '50 byte savings' accumulate anywhere in any meaningful or measurable sense whatsoever. So no, it doesn't "add up" to anything.
And if you're going to downvote me explain why I am wrong and how the benefit of these mythical 'savings' can be demonstrated.