That's a void argument in the article. If they were serving pages with 500 bytes each this would indeed be a huge improvement, but no page is 500 bytes. I just opened 4chan.org, and the markup before <body> is already 1,836 bytes. The entire frontpage of /b/ is 114,428 bytes, and saving 50 is absolutely negligible. On the other hand, if saving single bytes was significant, there would be a lot more potential in the source by shortening CSS class names etc. rather than picking a short domain name.
EDIT: According to http://www.4chan.org/advertise, there are a total of 575,000,000 monthly page impressions.