This is false. "Little guys", think the guy mining with 1 or 2 USB thumbdrive-sized miners, make
more relative profit than large scale miners. Whether you spend $50 to mine at 3 gigahash/sec, or $50,000 to mine at 3,000 gigahash/sec, in theory the relative profit is the same, but the extra costs associated to the 1000x scale become non-negligible.
For the little guy, space, power, and cooling are effectively free. He makes use of space that was already available and unused (eg. his desk), cooling is easy (a few watts can be passively cooled), and power is so small (2.5W per port) that he effectively writes it off as insignificant.
But a large scale miner like friedcat has to build or rent a data center facility, has to pay for air conditioning units, has a electricity bill he cannot ignore as insignificant, has to pay people to deploy and maintain the dozen of racks, etc.
Source: I have been mining since 2010, at some point I was mining with 20 killowatt of GPUs (ten racks or so).