Datomic (free and pro) has an "in memory" version that I used when developing my Clojure application. Makes firing off test-cases super simple and nice.
I used fixtures (edn) for the schema and for example data as well.
I would reload/dump/interact with the in-memory database in my REPL directly. Quite nice.
You can run a test instance (free/dev, which uses H2), that's no big deal to setup either, same as running a local MongoDB or PostgreSQL instance. Ease-of-configuration is on par with MongoDB but with sane defaults. It "just works".
I use environment variables for configuration, so the default Datomic database is just an in-memory instance, but I can point it to a localhost free instance easily.
Whether I use a free instance or an in-memory instance depends on whether or not I need the full transaction log. Typically no, but the migration toolkit I'm working on requires a persistent database so the defaults there are different for testing/development.
I'm seriously in love with a database that has a embedded and "real world" modes of operation with parity in their functionality (except for the log).