I don't think the fact that a diet book is a best-seller says a whole lot, especially when you consider that the same people who bought this book probably helped to make the Atkins, South Beach, etc. diet books the best sellers they were.
I haven't tried it, either, even though I should be losing weight. One reason for that is the same reason I haven't tried appetite-suppressants: I don't typically eat because I feel hungry, but because I want to be eating, so removing hunger seems useless; I hardly ever feel it, anyway.
Buuuttt...
Look at hacking your body the same way you would look at hacking a computer. What makes your metabolism tick?
What you're going to find is that excersizing, and eating a LOT of proteing (so that your body doesn't metabolize muscle tissue [like your heart] while you're on your uber low cal diet) are the best way to lose weight.
Don't eat anything (or very little) for like 2 days and the thought of eating a black and blue burger will start to seem repulsive. This is when you start eating fruit and chicken.