Go look at the top 250 addresses, a _majority_ of them have never been spent from. There isn't any conclusive proof that the #1 address (111,111 BTC) belongs to DPR, but it is clearly linked to SR in one way or another. I'd be willing to bet a solid amount of my own holdings that those coins are effectively "dead" (private key lost) along with a good portion of the rest of the addresses that haven't been touched since 2011, or have flat out never been spent from.

Everyone is touting the 12 million number for total coins in circulation right now and 21 million as the maximum amount. In practice both of those numbers are going to be significantly lower.