I'm always as truthful as possible in a job interview - especially technical ones. My background is not in tech, however I'm an autodidact with programming and whenever technical questions are asked that I may not know, I'll say it. And then I'll say how I think it should/would be done, or the steps I'd take to figure out the answer and solve the problem. Not sugarcoating some of my technical inability has faired me well so far. And then after I hear the question, think about the steps to do it, and/or get coached by the interviewee - I know the answer, and am ready to use it in my technical/creative arsenal. I feel like it's a win-win to not bullshit about something I don't know.
If you only get "I don't know" with no attempt at a guess or explanation for why they don't know then you may have issues.
I usually give a little preamble telling them to feel comfortable blurting out nonsense. I'd rather have them blurt out nonsense than sit there for 30 seconds in silence because they're afraid to say something stupid.
You can see the interviewee relax almost immediately.