You'll get sick in the stomach long before any effect on your eyes in any case - having it on for hours on end is extremely unrealistic right now.
There are other subtle effects like fish-eye that are lead to a disoriented feeling when I take off the Oculus.
Think of it this way: your cortex is always learning. Always. So if you present visual input that is subtly different (eye-spacing, fish-eye / pin-cushion, lag) for long periods your brain will learn that. Take it away and you've effectively got mild (hopefully reversible) brain damage wrt the physical world.
E.g. if you walk up to a wall in the Tuscany demo, it'll look like the wall at the center of your view is slightly closer to you than the wall off-center. It's not such a bad artifact in-game, but when I take the goggles off, flat walls IRL look slightly bowed away from my center of view for a while, and things feel ... different.
It's similar to when you stare at a scrolling screen, and then look at a fixed object. The object seems to be moving in the opposite direction.
Or a 50" TV screen.
For that to be of any practical benefit, it'd have to be 4K resolution, right?If you're just feeding that 50" TV a standard 1080p signal, you're not going to be able to display significantly more code than you'd be able to display on a 23" screen that's also running at 1080p.
Heck, cover the side of a building with a 1080p projector image, and a 27" monitor running at 2560x1400 will still show more code. :)